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Name

PALINDROME

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Status The current release has 0 entries and was indexed 14-Sep-2004.
Creation date Written (1999) - Mark Faller.
Description PALINDROME application details page

Looks for inverted repeats in a nucleotide sequence

palindrome looks for inverted repeats (stem loops) in anucleotide sequence.

It will find inverted repeats that include a proportion of mismatchesand gaps (bulges in the stem loop).

It works by finding all possible inverted matches satisfying thespecified conditions of minimum and maximum length of palindrome,maximum gap between repeated regions and number of mismatches allowed.

Secondary structures like inverted repeats in genomic sequences may beimplicated in initiation of DNA replication.

Some genomic sequence entries in the databases are composed ofunfinished, draft sequence with gaps of unknown size between contigs. The positions of these gaps are often indicated by runs of 200 Ncharacters. To prevent palindrome producing large, uninformativeoutputs, any palindromes found that are composed only of N's will not bereported.

Literature Some references on inverted repeats:
  1. Pearson CE, Zorbas H, Price GB, Zannis-Hadjopoulos M Inverted repeats, stem-loops, and cruciforms: significance for initiation of DNA replication. J Cell Biochem 1996 Oct;63(1):1-22
  2. Waldman AS, Tran H, Goldsmith EC, Resnick MA. q Long inverted repeats are an at-risk motif for recombination in mammalian cells. Genetics. 1999 Dec;153(4):1873-83. PMID: 10581292; UI: 20050682
  3. Jacobsen SE Gene silencing: Maintaining methylation patterns. Curr Biol 1999 Aug 26;9(16):R617-9
  4. Lewis S, Akgun E, Jasin M. Palindromic DNA and genome stability. Further studies. Ann N Y Acad Sci. 1999 May 18;870:45-57. PMID: 10415472; UI: 99343961
  5. Dai X, Greizerstein MB, Nadas-Chinni K, Rothman-Denes LB Supercoil-induced extrusion of a regulatory DNA hairpin. Proc Natl Acad Sci U S A 1997 Mar 18;94(6):2174-9
WWW www.hgmp.mrc.ac.uk/Software/EMBOSS/Apps/palindrome.html
Ftp The latest version of the EMBOSS package is available on ftp://ftp.uk.embnet.org/pub/EMBOSS/
Contact This application was written by Mark Faller (mfaller@hgmp.mrc.ac.uk)
See also
EINVERTED Finds DNA inverted repeats
EQUICKTANDEM Finds tandem repeats
ETANDEM Looks for tandem repeats in a nucleotide sequence
Data-fields in SRS
Field Name
Short Name
Type
No. of Keys
No. of Entry References
Indexing Date
Status
ID id id 0 0   not indexed
JobName jnm index 0 0   not indexed
Loaders
EMBOSSDNASIMPLESEQ
EMBOSSPROTSIMPLESEQ
SRS Description Structure ( srsgen.i , srsdb.i , href.i )
Syntax
Information
SRS Release 7.1.3    Copyright © 1997-2003 LION bioscience AG. All Rights Reserved. Terms of Use Feedback