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T*
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T*
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[(Myelin)-336(basic)-330.5(protein)-10647.3(AY860977)-5061(F:)-329.8(CCGTCGTGGAGACGTCAA)]TJ
29.2498 -1.1065 TD
[(R:)-329.6(CGAGGAGAGGACACAAAGCT)]TJ
/F12 1 Tf
-37.185 -1.448 TD
(Mpz)Tj
/F6 1 Tf
7.9353 0 TD
[(Myelin)-336(protein)-334.6(zero)-10935.2(BC164044)-5185(F:)-329.8(TGATCCTCGTTGTGGCAATTT)]TJ
29.2498 -1.1128 TD
[(R:)-329.6(CTTTCTTGCCATGTTTGCTCAT)]TJ
/F12 1 Tf
-37.185 -1.4416 TD
(Plp1b)Tj
/F6 1 Tf
7.9353 0 TD
[(Proteolipid)-339.1(protein)-334.6(1b)-9975.2(NM_001005586)-2738(F:)-329.8(TGCAAAGCACCAGAGTTCCA)]TJ
29.2498 -1.1128 TD
[(R:)-329.6(AGGGCAAGAAGGGTGATTCC)]TJ
/F12 1 Tf
-37.185 -1.4416 TD
(ZwiA)Tj
/F6 1 Tf
7.9353 0 TD
[(Zwilling-A)-14913.8(FJ221370)-5623(F:)-329.8(CTGTCTGTGGGTGGCTCTTCA)]TJ
29.2498 -1.1128 TD
[(R:)-329.6(GTGACCCCACGGGTGATG)]TJ
/F12 1 Tf
-37.185 -1.4416 TD
(ZwiB)Tj
/F6 1 Tf
7.9353 0 TD
[(Zwilling-B)-15079.8(FJ221370)-5623(F:)-329.8(GAACCTGGGAAGCACATCGA)]TJ
29.2498 -1.1128 TD
[(R:)-329.6(GGAGGAGCCCAGGGATGTT)]TJ
/F12 1 Tf
-37.185 -1.4479 TD
(36k)Tj
/F6 1 Tf
7.9353 0 TD
[(36k)-18200.8(BC114254)-5185(F:)-329.8(GAGGCAGATACGACGGCACTA)]TJ
29.2498 -1.1065 TD
[(R:)-329.6(GTGGATGCTGGGATGAGCTT)]TJ
/F12 1 Tf
-37.185 -1.4479 TD
(Olig2)Tj
/F6 1 Tf
7.9353 0 TD
[(Oligodendrocyte)-337.6(transcription)-342.9(factor)-332(2)-2737.3(NM_178100)-4238(F:)-329.8(GCGCGCAACTACATCCTTATG)]TJ
29.2498 -1.1065 TD
[(R:)-329.6(CTCCCTCCGCCGTAGATCTC)]TJ
/F12 1 Tf
-37.185 -1.4479 TD
(Olig1)Tj
/F6 1 Tf
7.9353 0 TD
[(Oligodendrocyte)-337.6(transcription)-342.9(factor)-332(1)-2737.3(NM_001020796)-2738(F:)-329.8(AGGAAGATCAACAGCCGTGAA)]TJ
29.2498 -1.1128 TD
[(R:)-329.6(GGCACCATGACTTCCCGTAA)]TJ
/F12 1 Tf
-37.185 -1.4416 TD
(Sox10)Tj
/F6 1 Tf
7.9353 0 TD
[(SRY)-335.7(\(sex-determining)-340.2(region)-337.2(Y\)-box)]TJ
.999 -1.1128 TD
[(containing)-339.8(gene)]TJ
18.7538 1.1128 TD
[(BC078333)-5185(F:)-329.8(ATATCCGCACCTGCACAA)]TJ
9.497 -1.1128 TD
[(R:)-329.6(CGTTCAGCAGTCTCCACAG)]TJ
/F12 1 Tf
-37.185 -1.4416 TD
(Kif1b)Tj
/F6 1 Tf
7.9353 0 TD
[(Kinesin)-334(family)-337.8(member)-335.2(1b)-7951.8(NM_194382)-4238(F:)-329.8(CAGGACCCCTTCTATGATCGTT)]TJ
29.2498 -1.1128 TD
[(R:)-329.6(TCACTACAGCGACTCGATGCA)]TJ
/F7 1 Tf
-37.185 -1.4416 TD
(b)Tj
/F12 1 Tf
.5564 0 TD
(-actin)Tj
/F7 1 Tf
7.3788 0 TD
(b)Tj
/F6 1 Tf
.5501 0 TD
[(-actin)-16768.7(BC045879)-5185(F:)-329.8(CCCTGTTCCAGCCATCCTT)]TJ
28.6997 -1.1128 TD
[(R:)-329.6(TTGAAAGTGGTCTCGTGGATACC)]TJ
7.9702 0 0 7.9702 67.748 431.433 Tm
[(F,)-329(forward)-328(primer;)-326.7(R,)-328.8(reverse)-333.4(primer.)]TJ
ET
q
1 i
60.321 378.368 m
298.261 378.368 l
298.261 133.795 l
60.321 133.795 l
W n
q
238.023 0 0 244.573 60.321 133.795 cm
/Im1 Do
Q
Q
BT
/F8 1 Tf
8.9663 0 0 8.9663 59.7543 117.0141 Tm
[(FIG.)-317.8(1.)]TJ
/F6 1 Tf
4.0783 0 TD
[(Survival)-312.1(rate)-316.7(\(percentage)-319.1(surviving)-316.9(throughout)-318.3(the)]TJ
-4.0783 -1.1065 TD
[(whole)-586.6(experiment)-590.6(compared)-585.8(with)-584.4(the)-591.8(initial)-586.6(number\))-583.2(of)]TJ
0 -1.1128 TD
[(adult)-311.4(female)-310.7(zebrash)-308.9(after)-310.9(1)-163.9(h)]TJ
/F8 1 Tf
13.9989 0 TD
(\(A\))Tj
/F6 1 Tf
1.7198 0 TD
[(or)-313.3(continuous)-310.5(24)-169.7(h)]TJ
/F8 1 Tf
8.4664 0 TD
(\(B\))Tj
/F6 1 Tf
1.6187 0 TD
(of)Tj
-25.8038 -1.1128 TD
[(daily)-368.1(exposure)-363.5(to)-363.6(nicotine)-364(at)-366.7(a)-359.9(concentration)-372.9(of)-363.6(1,)-356.5(5,)-362.8(10,)-362.3(15,)]TJ
0 -1.1065 TD
[(20,)-349.7(25,)-343.4(or)-344.9(30)]TJ
/F7 1 Tf
5.6274 0 TD
(l)Tj
/F6 1 Tf
.5564 0 TD
[(M.)-343.1(Survival)-350(was)-343.9(assessed)-349(at)-347.7(1)-340.9(day,)-345(10)-346.8(days,)-346.3(1)]TJ
-6.1838 -1.1128 TD
[(month,)-263.4(2)-258.7(months,)-264.7(3)-258.7(months,)-258.4(and)-258.8(4)-258.8(months)-268.1(of)-256.2(treatment)-267.9(\()]TJ
/F12 1 Tf
24.7352 0 TD
(n)Tj
/F10 1 Tf
.7145 0 TD
(=)Tj
/F6 1 Tf
.7208 0 TD
(7)Tj
-26.1705 -1.1128 TD
[(per)-337.1(group\).)]TJ
/F4 1 Tf
0 77.228 TD
[(REGULATION)-339.9(OF)-331.2(MYELIN)-338.2(BY)-335.8(NICOTINE)]TJ
54.1178 0 TD
(3)Tj
ET
endstream
endobj
52 0 obj
<>stream
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